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KMID : 1023520170400020143
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Korean Journal of Veterinary Service
2017 Volume.40 No. 2 p.143 ~ p.147
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Phenobarbital and zonisamide treatment of a cat with epilepsy of unknown cause
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Lee Ki-Ho
Park Jun-Seok
Kim Jung-Kook
Seo Kyoung-Won
Song Kun-Ho
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Abstract
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A Korean domestic short hair (1-year-old, male) presented with 2 to 3 weeks of seizures, aggressive behavior, vomiting, anorexia, and lethargy. The frequency of seizure had gradually increased from once a week to once every 3 hours. Physical and neurologic examination, diagnostic screening tests, including complete blood count (CBC), serum chemistry, electrolyte, coagulation test, X-ray, ultrasonography, and urinalysis were performed. Feline Leukemia Virus (FeLV), Feline Immunodeficiency Virus (FIV) and Toxoplasma spp. All tested negative, but the Feline Corona Virus (FCoV) kit revealed a positive result. To determine the exact diagnosis, magnetic resonance imaging (MRI) was performed but yielded no specific findings. The patient was then diagnosed with idiopathic epilepsy and treatment of phenobarbital was initiated. A month`s treatment with phenobarbital proved ineffective as symptoms worsened. Zonisamide was then selected as an additional anticonvulsant. After adding zonisamide, symptoms improved, and seizures abated for 15 months. This is the first case report in South Korea describing the use of phenobarbital and zonisamide in the treatment of a cat with idiopathic epilepsy.
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KEYWORD
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Feline, Idiopathic epilepsy, Magnetic resonance imaging (MRI), Phenobarbital, Zonisamide
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