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KMID : 1023520180410040239
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Korean Journal of Veterinary Service
2018 Volume.41 No. 4 p.239 ~ p.244
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Effects of selenate and L-glutamate on the growth of Mycobacterium tuberculosis complex
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Kim Seung-Cheol
Kim Jin-Sook
Monoldorova Sezim
Cho Jang-Eun
Hong Min-Sun
Jeon Bo-young
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Abstract
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Mycobacterium tuberculosis (M. tuberculosis) complex is the causative agent of tuberculosis (TB) in humans and bovine TB in mammalian hosts and grows very slowly. Selenium is a central molecule in nitrogen metabolism and an essential ingredient for all living cells and glutamic acid. The effects of selenium on the growth of M. tuberculosis, a representative slow-growing Mycobacterium species, were investigated and measured using the BacT Alert 3D System (MB/BacT System). Sodium selenate, at a final concentration of 10 μg/mL, reduced the average time-to detection (TTD) to 197.2 hours (95% confidence interval (CI), 179.6∼214.8) from 225.1 hours (95% CI, 218∼232.0) in the control culture media (P＜0.05). The TTD did not increase with L-glutamate concentrations up to 10 μg/mL, but a significant reduction in the TTD was observed in the presence of 20 μg/mL L-glutamate in culture media (P＜0.05). In conclusion, selenate and L-glutamate enhance the growth of M. tuberculosis.
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KEYWORD
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M. tuberculosis complex, Sodium selenate, L-glutamate
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