|
KMID : 1023520210440040299
|
|
Korean Journal of Veterinary Service
2021 Volume.44 No. 4 p.299 ~ p.303
|
|
|
Primary diffuse hepatocellular carcinoma in a captive polar bear (Ursus maritimus)
|
|
Krisdianti
Kim Tae-Yeon
Aufa Sulhi
Lee Sang-Joon
Ahn Sang-Jin
Cho Ho-Seong
Oh Yeon-Su
|
|
|
Abstract
|
|
|
|
A captive male polar bear (Ursus maritimus) was found dead after a long-term anorexia at a Park Zoo in Republic of Korea. At necropsy, the liver lesion was prominent with hepatomegaly carrying a big mass and numerous small nodules in various sizes. The cut surface of the nodules was creamy white, firm, and solid with umbilicated appearance. Histologically, there was proliferation of hepatocellular neoplastic cells arranged in glandular-like (pseudoglandular) pattern and complete loss of hepatocellular arrangement. The immunoreactivity for neoplastic hepatocyte antigens was positive for hepatocyte paraffin 1, and negative for vimentin, cytokeratin 7 and 19, and carcinoembryonic antigen. Based on those diagnostic features, the neoplasia was diagnosed as hepatocellular carcinoma. To the author’s knowledge, this is the first case report of hepatocellular carcinoma in the captive polar bear in Republic of Korea.
|
|
|
KEYWORD
|
|
|
Hepatocellular carcinoma, Immunohistochemistry, Polar bear
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|