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KMID : 1023620060300040271
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Reproductive and Developmental Biology
2006 Volume.30 No. 4 p.271 ~ p.277
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Expression Patterns of Receptor Type I, II and Substrate Proteins Smad 2, 3, 4 and 7 in Bovine Oocytes and Embryos
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Chung Hak-Jae
Kim Bong-Ki
Kim Jong-Mu
Lee Hyun-Gi
Han Joo-Hee
Kim Nam-Hyung
Park Jin-Ki
Seong Hwan-Hoo
Yang Boh-Suk
Chang Won-Kyong
Ko Yeoung-Gyu
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Abstract
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Transforming growth has been shown to have a positive effect on in vitro fertilization (IVF) and has been reported to stimulate meiosis at follicular level in variety of species. The study was designed to determine the expression patterns of receptors type I, II and Smads gene in bovine oocytes and embryos. and their receptors were observed in the unfertilized oocytes. and type II receptor were not expressed at the blastocyst stage, however, only type I receptor was exclusively observed at the same stage. The blastocyst stage, in particular, showed high levels of mRNA expression patterns containing a type I receptor. The mRNA expression pattern of Smad 2 at all stages of embryonic development was similar in all respect with type I receptor. On the contrary, Smad 3 and 4 were expressed with high and low level mRNA at the blastocyst stage. In conclusion. it is suggested that signaling may be regarded as an important entity during the preimplantation embryo development.
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KEYWORD
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Smads, Gene expression, Preimplantation embryo, Bovine
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