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KMID : 1023620100340020081
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Reproductive and Developmental Biology
2010 Volume.34 No. 2 p.81 ~ p.88
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Effect of Streptozotocin-Induced Diabetes on Bone and Heart Development in Juvenile Rats
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Kim Joo-Heon
Lee Young-Jeon
Lee Sang-Un
Suzuki Takao
Lee Sang-Kil
Kang Tae-Young
Hong Young-Geun
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Abstract
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Our objective of current study was to investigate the development of bone and heart in association with diabetes mellitus (DM). DM was induced by administering an intraperitoneal injection of streptozotocin (STZ; 60 mg/kg) to 4?gweek?gold Sprague?gDawley rats. Body weight and blood glucose were monitored, and rats were sacrificed after 2 or 5 weeks. The left ventricle (LV), including the interventricular septum, was weighed, and body weight and tibial bone length were assessed. Young diabetic rats showed reduced growth in terms of tibial length and body weight compared to controls. Moreover, diabetic males showed more significant growth suppression and reduced LV size than diabetic females. Morphometric analysis of tibiae from diabetic rats revealed suppressed bone growth at 2 and 5 weeks, with no difference between genders. STZ?ginduced diabetes decreased bone growth and retarded pre?gpubertal heart development. As a result, diabetes may increase cardiovascular risk factors and lead to eventual heart failure. Therefore, new therapeutic approaches are required for diabetic children exhibiting growth retardation. Heart growth factor, exercise, and cardiopulmonary physical therapy may be required to promote heart development and physiological function.
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KEYWORD
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Diabetes, Growth retardation, Hypertrophy, Streptozotocin(STZ), Tibial bone length
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