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KMID : 1023620110350030411
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Reproductive and Developmental Biology
2011 Volume.35 No. 3 p.411 ~ p.416
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Long-term Hematologic Characteristics of Korean Native Beef Cattle (Hanwoo) Derived from Somatic Cells Nuclear Transfer
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Yang Byoung-Chul
Lee Hwi-Cheul
Chung Hak-Jae
Kim Kyung-Woon
An Jin-Hee
Chung Hee-Kyoung
Kim Dong-Hoon
Byun Sung-June
Im Gi-Sun
Park Jin-Ki
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Abstract
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The purpose of the production of somatic cell cloned animals through cloning excellent cattle meat and milk production. However, at birth or after birth in cloned animal health problems such as the large offspring syndrome, malformations and sudden death has already been reported. Successfully overcome the initial problems of cloning animals for growing that there are other issues will need to continue to monitor. The objective of this study was to determine the long term health status for the cloned bovine and their offspring. Whole blood collected from 83 months (9 cow) female clone, 72 months (1) male clone and their offspring and hematological analysis was performed. To collect basic data about the safety of cloned animals and their offspring the RBC, WBC, cytokine were scanned. As a result, the red blood cells, HCT, Hb, MCV, MCH, MCHC levels between cloned animals and the controls did not differ significantly. White blood cells, platelet, S. neutro, lymphocyte, monocyte, eosinophil levels, protein, albumin, Bilirubin, γ-GT, K, amylase, creatinine, glucose, calcium, Mg, insulin-like growth factor 1(IGF-1), TNF-a, IL-6, IL-10 levels between clone and control cow are no different significantly. The immune globulin and potassium levels showed differences, however, the difference between normal and within reference range. These results suggested that health status of cloned animal and their funder is not something to worry about until now. Although, between clone and control was no difference in hematological characteristics, these and other factors, but also the long-term research will be needed.
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KEYWORD
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Cloned cattle, Hematological characteristics
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