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KMID : 1023620110350040421
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Reproductive and Developmental Biology
2011 Volume.35 No. 4 p.421 ~ p.425
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Novel Disease Model of Chronic Neutrophilic Leukemia
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Seo Byoung-Boo
Min Sung-Hun
Lee Eun-Ji
Ryoo Zae-Young
Park Hum-Dai
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Abstract
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The experimental manipulation of protooncogenes and their gene products is a valuable research tool for the study of human neoplasia. In this study, the recently identified human cervical cancer protooncogene (HccR-2) was expressed in transgenic mice under the control of the tetracycline regulatory system. The phenotype observed was similar in many respects to human chronic neutrophilic leukemia (CNL). Thus, the HccR-2 transgenic mouse model is important not only for investigating the biological properties of the HccR-2 protooncogene in vivo, but also for analyzing the mechanisms involved in the progression of CNL.
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KEYWORD
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Human cervical cancer, Protooncogene, Transgenic mice, Chronic neutrophilic leukemia
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