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KMID : 1023620110350040457
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Reproductive and Developmental Biology
2011 Volume.35 No. 4 p.457 ~ p.461
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The Effect of Jazf1 Overexpression in Zebrafish Cardiac Development
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Shin Mi-Jung
Yuh Hyung-Soo
Seo Byoung-Boo
Park Hum-Dai
Yoon Du-Hak
Ryoo Zae-Young
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Abstract
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JAZF1 (Juxtaposed with Another Zinc Finger gene 1) transcription factor are Zn-finger proteins that bind to the nuclear orphan receptor TAK/TR4 (Nakajima et al., 2004). The nuclear orphan receptor TAK1/TR4 functions as a positive as well as a negative regulator of transcription. It was recently reported that congenital cardiovascular malformations are significantly more frequent in Neurofibromatosis 1 (NF1) patients with microdeletion syndrome than in those with classical NF1. JAZF1 was expressed in adult heart of patients with microdeletion syndrome. JAZF1 is highly conserved among various species include zebrafish. We hypothesized that the expression of zebrafish Jazf1 may lead to severe forms of congenital heart disease that allow the survival of newborns and adults. In this study, we created Jazf1 transgenic zebrafish which over-express zebrafish Jazf1 cDNA under control of the CMV promoter. Our results suggested that Jazf1 expression may play an important role in zebrafish cardiac development.
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KEYWORD
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Jazf1, zebrafish, cardiac development, heart looping
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