|
KMID : 1023620130370040185
|
|
Reproductive and Developmental Biology
2013 Volume.37 No. 4 p.185 ~ p.192
|
|
|
Gene Co-Expression Network Analysis of Reproductive Traits in Bovine Genome
|
|
Lim Da-Jeong
Cho Yong-Min
Lee Seung-Hwan
Chai Han-Ha
Kim Tae-Hun
|
|
|
Abstract
|
|
|
|
Many countries have implemented genetic evaluation for fertility traits in recent years. In particular, reproductive trait is a complex trait and need to require a system-level approach for identifying candidate genes related to the trait. To find the candidate gene associated with reproductive trait, we applied a weighted gene co-expression network analysis from expression value of bovine genes. We identified three co-expressed modules associated with reproductive trait from bovine microarray data. Hub genes (ZP4, FHL2 and EGR4) were determined in each module; they were topologically centered with statistically significant value in the gene co-expression network. We were able to find the highly co-expressed gene pairs with a correlation coefficient. Finally, the crucial functions of co-expressed modules were reported from functional enrichment analysis. We suggest that the network-based approach in livestock may an important method for analyzing the complex effects of candidate genes associated with economic traits like reproduction.
|
|
|
KEYWORD
|
|
|
Reproduction, Gene Co-expression Network (GCN), Cattle
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|