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KMID : 1023620150390020037
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Reproductive and Developmental Biology
2015 Volume.39 No. 2 p.37 ~ p.41
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Role of Golgi Apparatus on Regulation of Sec61β, COPG2 and Epidermal Growth Factor during Oocyte Maturation
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Oh Hae-In
Lee Sang-Hee
Lee Seung-Hyung
Lee Seung-Tae
Lee Eun-Song
Park Choon-Keun
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Abstract
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The oocyte undergoes various events during maturation and requires many substances for the maturation process. Various intracellular organelles are also involved in maturation of the oocyte. During the process glucose is essential for nuclear and cytoplasmic maturation, and adenosine triphosphate is needed for reorganization of the organelles and cytoskeleton. If mitochondrial function is lost, several developmental defects in meiotic chromosome segregation and maturation cause fertilization failure. The endoplasmic reticulum, a store for Ca²+, releases Ca²+ into the cytoplasm in response to various cellular signaling molecules. This event stimulates secretion of hormones, growth factors and antioxidants in oocyte during maturation. Also, oocyte nuclear maturation is stimulated by growth factors such as epidermal growth factor. This review summarizes roles of organelles with focus on the Golgi apparatus during maturation in oocyte.
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KEYWORD
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Golgi apparatus, Oocyte maturation, Sec61β, COPG2, Epidermal growth factor
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