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KMID : 1023620170410010001
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Reproductive and Developmental Biology
2017 Volume.41 No. 1 p.1 ~ p.6
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Studies on Steroid Hormone Concentration during the Estrous Cycle in the MediKinetics Micropig®
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Seong Hun-Ki
Seo Kyeong-Seok
Kim Jeong-Su
Her Chang-Gi
Kang Myung-Hwa
Sim Bo-Woong
Yoon Jong-Taek
Min Kwan-Sik
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Abstract
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In all mammalian species, progesterone is essential to both the preparation for, and maintenance of, pregnancy. The 20α-hydroxysteroid dehydrogenase (20α-HSD) enzyme predominantly converts progesterone into its biologically inactive
form 20α-hydroxyprogesterone, thereby regulating its activity. Thus, to directly assess sexual maturation in the MediKinetics micropig®, we analyzed the concentration of the steroid hormones progesterone and estradiol dur ing the
estrous cycle. Our results show that the progesterone level exhibited by the analyzed micorpig® was low at the beginning of the estrous cycle, and then abruptly increased to 30.32±10.0 ng/mL and 46.37±11.0 ng/mL by days 9 and 11 of the cycle, respectively. It reached the highest level 55.87±3.5 ng/mL on day 13 of the estrous cycle, before decreasing to 46.58± 13.1 ng/mL and 10.0±7.6 ng/mL by days 15 and 17 of the cycle, respectively. In contrast, the estradiol level was shown to be highest (27.13±11.2 ng/mL) at the initiation of the estrous cycle, after which point it decreased to 13.29±6.5 ng/mL and 10.94±5.9 ng/mL by days 4 and 5 of the estrous cycle, respectively. By day 17 of the estrous cycle, the estradiol level decreased to 4.13±7.6 ng/mL. We anticipate that these results will provide useful information to enable the study of human ovulation and reproductive physiology using the MediKinetics micoripig® as a model system. We recommend further investigation to elucidate the functional mechanisms underlying the regulation of sexual maturation in the MediKinetics micropig®.
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KEYWORD
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Steroid hormone, Progesterone, Estradiol, Estrous cycle, MediKinetics Micropig®
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