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KMID : 1023620170410010017
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Reproductive and Developmental Biology
2017 Volume.41 No. 1 p.17 ~ p.23
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Effects of Reactive Oxygen Species and Antioxidants during In Vitro Maturation Oocytes and Embryo Development in Pigs
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Lee Won-Hee
Park Ji-Eun
Hwangbo Yong
Kim Hwa-Young
Lee Ji-Eun
Kang Byeong-Buhm
Cheong Hee-Tae
Yang Boo-Keun
Park Choon-Keun
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Abstract
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The oocyte undergoes various events during in vitro maturation (IVM) and subsequence development. One of the events is production of reactive oxygen species (ROS) that is a normal process of cell metabolism. But imbalances between ROS production and antioxidant systems induce oxidative stress that negatively affect to mammalian reproductive process. In vitro environments, in vitro matured oocytes have many problems, such as excessive production of ROS and imperfect cytoplasmic maturation. Therefore, in vitro matured oocytes still have lower maturation rates and developmental competence than in vivo matured oocytes. In order to improve the IVM and in vitro culture (IVC) system, antioxidants, vitamins were added to the IVM, IVC medium. Antioxidant supplementation was effective in controlling the production of ROS and it continues to be explored as a potential strategy to overcome mammalian reproductive disorders. Based on these studies, we expect that the use of antioxidants in porcine oocytes could improved maturation and development rates.
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KEYWORD
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Reactive oxygen species, Antioxidant, In vitro maturation, Embryo development
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