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KMID : 1023620170410020033
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Reproductive and Developmental Biology
2017 Volume.41 No. 2 p.33 ~ p.40
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X-Chromosome Inactivation: A Complex Circuits regulated by Non-coding RNAs and Pluripotent Factors
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Hwang Jae-Yeon
Lee Chang-Kyu
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Abstract
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X-chromosome inactivation is one of the most complex events observed in early embryo developments. The epigenetic changes occurred in female X-chromosome is essential to compensate dosages of X-linked genes between males and females. Because of the relevance of the epigenetic process to the normal embryo developments and stem cell studies, X-chromosome inactivation has been focused intensively for last 10 years. Initiation and regulation of the process is managed by diverse factors. Especially, proteins and non-coding RNAs encoded in X-chromosome inactivation center, and a couple of transcription factors have been reported to regulate the event. In this review, we introduce the reported factors, and how they regulate epigenetic inactivation of X-chromosomes.
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KEYWORD
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X-chromosome inactivation, X-chromosome inactivation center, Pluripotent factors
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