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KMID : 1024620010210040374
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Food Science of Animal Resources
2001 Volume.21 No. 4 p.374 ~ p.382
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Effect of Lactoferrin from Korean Native Cattle on the Production of Tumor Necrosis Factor- and Nitric Oxid
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Lee Su-Won
Yang Hee-Jin
Hwangbo S.
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Abstract
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Lactoferrin(Lf) has the function of modulation in the host defense systems, including cytokine production and immune responses. We have tested the effect of Lf and Lf ydrolysates(Lf-H) on the productions of tumor necrosis factor-(TNF-) and nitric oxide(NO) in macrophage cells. Lf from Korean native cattle(K-Lf) and hydrolyzed K-Lf(K-Lf-H) increased the production of TNF- in RAW264.7 cells with dose-dependency. Bovine Lf(B-Lf), human Lf(H-Lf), and its hydrolysates did not induce either TNF- production or NO production. On the other hand those didn\`t affect on the production of TNF- in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. K-Lf induced the production of NO similar to its role on the TNF- production.
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KEYWORD
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lactoferrin, tumor necrosis factor-, nitric oxide, lipopolysaccharide
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