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KMID : 1024620020220010072
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Food Science of Animal Resources
2002 Volume.22 No. 1 p.72 ~ p.76
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Antitumor Activity of -Lactalbumin on the Tumor Cells
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Lee Su-Won
Shin Young-Ha
Hwangbo S.
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Abstract
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Bovine serum albumin(BSA), -lactalbumin(-LA), -lactoglobulin(-LG) and bovine immunoglobulin G (IgG) were investigated the cytotoxicity on tumor cell lines. -LA was showned a tendency of dose dependaent on cytotoxicity using WiDr. The growth of WiDr was inhibited 82% by 1mg/ml of -LA. However, IgG, BSA and -LG were not shown the cytotoxicity on WiDr. When -LA was purified by using high pressure liquid chromatography(HPLC), the main component(-LA) was eluted at 33.057 min and extremely small quantities eluted at 32.310 min. The cytotoxicity of main component (eluted at 33.057 min peak) was lower than commercial -LA. And the cytotoxic activity of hydrolyzed -LA and -LA treated with EDTA were lower than commercial -LA on tumor cells.
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KEYWORD
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α-lactalbumin, cytotoxicity, whey protein, MTT assay
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