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KMID : 1024620050250040465
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Food Science of Animal Resources
2005 Volume.25 No. 4 p.465 ~ p.471
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The Safety and Clinical Test of Anti-Helicobacter pylori IgY
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Jung Soon-Hee
Kim Hyun-Jue
Lee Soo-Won
Lyoo Young-Soo
Park Hyung-Seok
Lee Nam-Hyung
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Abstract
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This study was carried out to evaluate the effectiveness of anti-Helicobacter pylori IgY powder to suppress infection of Helicobacter pylori in humans. Hens were immunized with H. pylori to produce a specific anti-H. pylori IgY in their egg yolks, and then anti-H. pylori IgY Powder was used a sample after egg yolks were harvested The safety tests of anti-H. pylori IgY powder were conducted a acute and subacute toxicity test, The result was that the mice fed IgY powder were normal state on a acute and subacute toxicity test The effect of anti-H. pylori IgY powder was evaluated by urease breath test, Volunteers who tested positive for H. pylori using a breath test were divided in two groups, one was administrated with anti-H. pylori IgY powder (11.2g/day) and natural extract mixture and the other was administrated with water soluble protein fraction (3.2g/day) of anti-H. pylori IgY powder, The results of clinical test in two groups were shown reduction of UBT value about 23 and 18 respectively. This result indicates that anit-H. pylori IgY is safety and can be used toy the effective supplement as an ingredient of functional food.
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KEYWORD
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IgY, egg yolk Powder, Helicobacter pylori
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