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KMID : 1024620080280020222
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Food Science of Animal Resources
2008 Volume.28 No. 2 p.222 ~ p.231
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A Study of the Efficacy of Hair Analysis Relative to Serum and Organ Analysis for Assessing Heavy Metal Reduction in Living Animals Treated with an Herbal Medicine Remnant and Organic Selenium
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Son Young-Hee
Yoo Ji-Eun
Heo Ji-Youn
Jang Sung-Pyo
Lee Byung-Soo
Lee Bo-Reum
Yun Seon-Gi
Lee Chi-Ho
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Abstract
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This study was carried out to develop a method for decreasing the heavy metal composition of living stock. Sprague-Dawley (SD) male rats were pre-treated with heavy metals administered i.p. at the limits of regulation according to the feed CODEX in Korea. Herbal medicine remnant was administered p.o. (2, 4 ppm of average feeding amount) for the entire period of study with organic selenium (2 ppm of average feeding amount) before any other treatment. 2,2’-azobis(2-amidinopropane) dihydrochloride (AAPH) was also administered i.p. in a single dose of 60 mg/kg body weight before animals were sacrificed. The TBARS test with the FOX assay demonstrates a decrease of heavy metals due to these functional materials in vitro. Moreover, this decrease in heavy metals was also demonstrated by in vivo tests based on SD rats hair analysis and organ analysis after 6 weeks. A good linear correlation between hair analysis and organ analysis represented by liver and blood was shown. The present findings suggest that measurement method of heavy metal composition using hair analysis for healthy livestock can be used in place of detection methods carried out by organ and blood analysis, and herbal medicines with organic selenium may be very effective at decreasing heavy metals of feed materials in feed manufacture industry.
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KEYWORD
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hair, organs, ICP, heavy metal analysis, herbal medicine remnant, organic selenium
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