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KMID : 1024620150350040507
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Food Science of Animal Resources
2015 Volume.35 No. 4 p.507 ~ p.514
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First Evidence that Sika Deer (Cervus nippon) Velvet Antler Extract Suppresses Migration of Human Prostate Cancer Cells
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Tang Yujiao
Jeon Byong-Tae
Wang Yan-mei
Choi Eun-Ju
Kim Yon-Suk
Hwang Jin-Woo
Park Pyo-Jam
Moon Sang-Ho
Kim Eun-Kyung
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Abstract
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Deer velvet antler (DVA) is one of the most popular medicines in China. Numerous studies have demonstrated that velvet antler possess biological effects. However, data regarding its anti-migration activity on prostate cancer is scarce. In this study, we investigated the inhibitory effect of top DVA (T-DVA) on the expression of prostate-specific antigen (PSA) and migration-related genes in the human prostate cancer cell, LNCaP. The T-DVA down-regulated the expression of PSA. In addition, the RadiusTM assay revealed that T-DVA inhibited the migration behavior of prostate cancer cells. Furthermore, the expression of matrix metalloproteinase (MMP)-9 and vascular endothelial growth factor (VEGF) was also decreased with T-DVA. On the contrary, T-DVA increased the tissue inhibition of metallo-proteinase (TIMP)-1 and (TIMP)-2. Taken together, our findings indicate that the T-DVA possesses anti-migration activity on prostate cancer cells. This is the first study of DVA to report the anti-migration activity on prostate cancer.
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KEYWORD
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Deer velvet antler, prostate cancer, PSA, migration
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