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KMID : 1033620110380010001
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Clinical and Experimental Reproductive Medicine
2011 Volume.38 No. 1 p.1 ~ p.5
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Small GTPases and formins in mammalian oocyte maturation: cytoskeletal organizers
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Kwon So-Jung
Lim Hyun-Jung
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Abstract
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The maturation process of mammalian oocytes accompanies an extensive rearrangement of the cytoskeleton and associated proteins. As this process requires a delicate interplay between the cytoskeleton and its regulators, it is often targeted by various external and internal adversaries that affect the congression and/or segregation of chromosomes. Asymmetric cell division in oocytes also requires specific regulators of the cytoskeleton, including formin-2 and small GTPases. Recent literature providing clues regarding how actin filaments and microtubules interact during spindle migration in mouse oocytes are highlighted in this review.
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KEYWORD
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Oocyte, Spindle, Formin, GTP Phosphohydrolases, Human, Mice
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