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KMID : 1033620110380010006
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Clinical and Experimental Reproductive Medicine
2011 Volume.38 No. 1 p.6 ~ p.9
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Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility
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Lee Sun-Hee
Lee Su-Man
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Abstract
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Objective: To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility.
Methods: We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping.
Results: The SNP of the KLK2 gene had a statistically significant association with male infertility (p<0.05). The odds ratio for the minor allele (+255A) in the pooled sample was 0.47 (95% confidence intervals, 0.26-0.85) for rs2664155.
Conclusion: The relationship of KLK2 SNP to male infertility is statistically significant, especially within the non-azoospermia group. Further study is needed to understand the mechanisms associated with male infertility.
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KEYWORD
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Kallikrein-related Peptidase 2, Polymorphism, Single Nucleotide, Infertility, Male, Human
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