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KMID : 1034820050010010007
Molecular & Cellular Toxicology
2005 Volume.1 No. 1 p.7 ~ p.12
Development of Proteomics and Applications of Proteomics in Toxicolog
Jung Woon-Won

Huh Yoon-Ee
Ryu Jae-Chun
Lee Eun-Il
Sul Dong-geun
Abstract
Proteomics has recently received intense scientific interest after the completion of the Human Genome Project, because this genome-based high technology allows to search new drug targets or diagnostic markers. Many proteome projects including Human plasma proteome projects (HPPP), Human liver proteome projects (HLPP), Human brain proteome projects (HBPP), and Mouse and Rat Proteome Project (MRPP) have been carried out and proteomic analytical techniques have been developed in second dimensional electrophoresis (2-DE) and LC/MS system. This powerful method has been applied in toxicology producing a new term "Toxicoproteomics". In this review, recent proteome projects, proteomic technologies, and toxicoproteomics will be discussed.
KEYWORD
LC/MS, plasma, proteomics, second dimensional electrophoresis, toxicology
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