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KMID : 1034820050010020106
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Molecular & Cellular Toxicology
2005 Volume.1 No. 2 p.106 ~ p.110
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Identification of Potential Carcinogenic Biomarker Following Exposure to N-ethyl-N-nitrosourea in Mice
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Lim Jung-Sun
Han Sang-Seop
Song Chang-Woo
Yoon Seok-Joo
Jeong Sung-Young
Hwang Ji-Yoon
Cho Kyu-Hyuk
Cho Jae-Woo
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Abstract
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N-ethyl-N-nitrosourea (ENU), which is a toxin and a carcinogen, as well as a mutagen, has a variety of effects on mice. ENU induces point mutation in male germ cell. Number of mutant animals are developed with ENU treatment. However, potentiality ot ENU as a carcinogen is not fully understood, even though, mutagenicity of ENU is broadly studied, In the present study, the gene expression profiling and histopathological investigation of ENU treated mouse’s liver and brain were investigated. Also, the expression patterns of cancer related genes in ENU-treated mouse were analyzed.
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KEYWORD
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ENU, carcinogen, gene expression, biomarker
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