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KMID : 1034820060020030212
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Molecular & Cellular Toxicology
2006 Volume.2 No. 3 p.212 ~ p.215
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Association of PAI-1 Polymorphism with Schizophrenia in Korean Population
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Yoon Seo-Hyun
Park Hae-Jeong
Zheng Longtai
Hong Mee-Suk
Kim Jong-Woo
Yim Sung-Vin
Chung Joo-Ho
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Abstract
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Several reports have suggested a possible relationship between blood coagulation factors and schizophrenia. Plasminogen activator inhibitor type 1 (PAI-1) belongs to a serine protease inhibitor family, which regulates fibrinolysis and proteolysis by inhibiting plasminogen activation. The purpose of this study was to investigate the association of polymorphisms of the PAI-1 gene with schizophrenia in Korean population. Two important polymorphisms (-675 4G/5G and -844 G/A) located on promoter region of the PAI-1 gene were analyzed on 178 schizophrenia patients and 226 controls. The genotypic and allelic associations of -675 4G/5G were found significant. Furthermore, haplotype analysis revealed significant result, which suggests that -675 4G/5G polymorphism might confer increased susceptibility for schizophrenia in Korean population.
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KEYWORD
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Plasminogen activator inhibitor 1, Schizophrenia, Polymorphism, Association
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