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KMID : 1034820070030020132
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Molecular & Cellular Toxicology
2007 Volume.3 No. 2 p.132 ~ p.136
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The Efficiency of Zinc-Aspartate Complex on Zinc Uptake in Plasma and Different Organs in Normal SD Rats
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Kim Yu-Ri
Kim Ki-Nam
Shim Boo-Im
Lee Seung-Min
Kim In-Kyoung
Sohn Sung-Hwa
Park Myung-Gyu
Park Hong-Seok
Kim Meyoung-Kon
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Abstract
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Zinc is essential metal and plays a role in a wide variety of physiological and biochemical processes. Prostate gland contains high level of zinc, generally 3-10 folds higher than other organs. Prostatic zinc uptake is resulted from the existence of zinc transporter (ZnT) protein families in membrane. In this study, we investigated the difference of zinc uptake efficiency of zinc-aspartate complex (Zn-Asp) into various organs compared with . We observed that Plasma zinc concentration in both and Zn-Asp administrated group was increased progressively following administration, and reached a peak level at 2 hr. The increasing pattern of zinc concentration was similar to each groups, however the zinc concentration of Zn-Asp administrated group was higher than that of administrated group. We found that prostatic zinc level of Zn-Asp administrated group was higher than administrated group, and was increased approximately 2.7 fold and 4.2 fold at 4 and 8 hr after administration. From these observations, we suggest than Zn-Asp has high uptake efficiency of zinc into the prostate gland. Therefore, Zn-Asp is potentially useful treatment of many prostatic diseases.
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KEYWORD
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Prostate gland, Zinc, Zinc-Ligand complex, Zinc transporter (ZnT)
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