|
KMID : 1034820070030040254
|
|
Molecular & Cellular Toxicology
2007 Volume.3 No. 4 p.254 ~ p.261
|
|
|
The Anti-Inflammatory Effect of IH-901 in HT-29 Cells
|
|
Lee Seung-Min
Kim Ki-Nam
Kim Yu-Ri
Kim Hye-Won
Shim Boo-Im
Lee Seung-Ho
Bae Hak-Soon
Kim In-Kyoung
Kim Meyoung-Kon
|
|
|
Abstract
|
|
|
|
20-O-(-D-Glucopyranosyl)-20 (S)-protopanaxadiol (IH-901) is one of the major metabolites of ginsenosides from Panax ginseng, and is suggested that IH-901 has been associated with various pharmacological and physiological activities. In this study, we demonstrate that IH-901 induced anti-inflammation in HT-29 human colon adenocarcinoma cells. Our results showed that IH-901 inhibited cell proliferation of HT-29 in a time- and dose-dependent manner. We also found that IH-901 was significantly decreased expression of iNOS compared with non-treated. We observed effect of IH-901 related with inflammatory genes using by cDNA microarray. We were known that the 34 inflammatory genes such as E2F, CDK6, TNF-, and PKC were down-regulated. Thus, these results suggest that IH-901 may have a potential preventive factor to improving cancer induced by chronic inflammation.
|
|
|
KEYWORD
|
|
|
IH-901, Inducible Nitric Oxide Synthase (iNOS), Nitric Oxide (NO), Inflammation, HT-29 human colon adenocarcinoma cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|