|
KMID : 1034820070030040262
|
|
Molecular & Cellular Toxicology
2007 Volume.3 No. 4 p.262 ~ p.266
|
|
|
Somatic Mutations of the ENPP2 (Autotaxin/lysoPLD) Gene in Breast Cancer
|
|
Song Jae-Hwi
Kim Jeong-Kyu
Noh Ji-Heon
Jung Kwang-Hwa
Eun Jung-Woo
Kim Chang-Jae
Bae Hyun-Jin
Xie Hong-Jian
Ahn Young-Min
Lee Sug-Hyung
Yoo Nam-Jin
Lee Jung-Young
Park Won-Sang
Nam Suk-Woo
|
|
|
Abstract
|
|
|
|
ENPP2, a 125 kDa secreted lysophopholipase D which originally identified as a tumor-motogen, Autotaxin, enhances cellular locomotion, cell proliferation, angiogenesis and cell survival by generating the signal molecule lysophosphatic acid or sphingosine-1-phosphate. Previous studies have suggested that expression of Autotaxin is associated with invasive phenotype in advanced breast carcinomas. Thus, to determine whether genetic alterations of ENPP2 gene are involved in the development or progression of breast cancer, we analyzed its somatic mutation in 85 breast carcinomas by single-stranded conformational polymorphism and sequencing. Overall, six ENPP2 mutations were found (7.0%), comprising five missense and one nonsense mutation (s). To our knowledge, this is the first report on ENPP2 mutation in breast carcinoma, and the data indicate that ENPP2 is occasionally mutated in breast carcinomas, and suggest that ENPP2 mutation may contribute to the tumor development in some breast carcinomas.
|
|
|
KEYWORD
|
|
|
ENPP2, Lysophospholipase D, Autotaxin, Breast cancer, Somatic mutation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|