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KMID : 1034820070030040314
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Molecular & Cellular Toxicology
2007 Volume.3 No. 4 p.314 ~ p.319
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Effects of CYP1A21C and CYP1A21F Genotypes on the Activity and Inducibility of CYP1A2 Determined by Urinary Caffeine Metabolite Ratio in Koreans
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Shin Mi-Kyung
Yi Hyeon-Gyu
Kwon Yong-Hyun
Lee Sung-Keun
Lim Woo-Sung
Park Chang-Shin
Kang Ju-Hee
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Abstract
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The effects of common variants of CYP1A2 gene (CYP1A21C and CYP1A21F) on the CYP1A2 activity and inducibility were controversial. The aim of the present study is to investigate the effects of CYP1A21C and CYP1A21F on the activity of CYP1A2 determined by urinary caffeine metabolite ratio in Koreans. As might be expected, there was large inter-individual variation (16-folds) of CYP1A2 activity ranged from 2.41 to 39.58. The mean CYP1A2 activity of smokers was significantly higher than that of non-smokers. The frequencies of CYP1A21C (-3858A) and 1F (-164A) alleles were 0.219 and 0.646, respectively. The effect of CYP1A21C on the CYP1A2 activity was not significant. However, the CYP1A2 activity of subjects with AA genotype for CYP1A21F allele was significantly lower than that of non-AA genotypes (CC, or CA). Interestingly, the significant effect of CYP1A21F allele on CYP1A2 activity was not observed in nonsmokers. Our results suggest that CYP1A21F allele rather than CYP1A21C allele significantly influences on the inducibility of CYP1A2 in Koreans. Owing to small sample size of our study, further studies should be conducted to reveal the inter-ethnic difference or the gene-environmental interaction.
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KEYWORD
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CYP1A2, Genotype, Inducibility, Caffeine metabolism, Korean
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