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KMID : 1034820080040020150
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Molecular & Cellular Toxicology
2008 Volume.4 No. 2 p.150 ~ p.156
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Photoprotective Effects of Minerals from Korean Indigenous Ores on UVA-irradiated Human Dermal Fibroblast
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Kang Dong-Kyu
Lee Mi-Young
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Abstract
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The photoprotective effects of minerals from Korean indigenous ores, consisting mainly of sericite, on UVA-irradiated human dermal fibroblast (HDF) were examined. Zymographic analysis showed that the treatment of the minerals significantly reduced the UVA-enhanced MMP-1 activity and mRNA level. The minerals also showed strong inhibitory effect on MMP-2 activity and mRNA expression. Moreover, the minerals were better than polyphenol in reducing MMP-1 and MMP-2 expressions. Notably, the minerals significantly enhanced collagen biosynthesis in the HDF. Inhibition of the elastase activity and protection against the oxidatively damaged HDF cell were also found in the presence of the minerals. Taken together, the ore minerals may be used as the potent photo-protective and anti-skin-aging ingredients which can prevent skin cell damage by UVA.
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KEYWORD
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Ore minerals, Human dermal fibroblast, Photo-protection
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