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KMID : 1034820080040040360
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Molecular & Cellular Toxicology
2008 Volume.4 No. 4 p.360 ~ p.365
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The Effect of Exposure to Mixed Organic Solvents on Lipid Peroxidation in Ship Building Painters
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Park Jun-Ho
Cha Bong-Suk
Chang Sei-Jin
Koh Sang-Baek
Eom Ae-Yong
Lee Kang-Myeung
Jung Min-Ye
Choi Hong-Soon
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Abstract
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In the last several years, studies on the association of oxidative stress damage with exposure in the work place have been conducted. Xenobiotics create an imbalance of the homeostasis between oxidant molecules and antioxidant defense. By monitoring oxidative stress biomarkers, information was obtained on damages induced by oxidative stress and the toxicity of xenobiotics. In the present study, a Job Exposure Matrix (JEM) was constructed using the data from the Working Environment Measurement (WEM) of painters in the shipyard industry from the past 3 years to assess the exposure status. Additionally, by measuring the concentration of urinary malondialdehyde (MDA), the effect of lipid peroxidation was examined. The subjects consisted of 68 workers who were exposed to mixed organic solvents in the painting process and 25 non-exposure controls. The exposure indices of the exposure groups were significantly different (sprayer: 0.83, touchup: 0.54, assistant: 0.13, P<0.05). The urinary MDA concentration of the exposure group was 48.60 39.23 /mol creatinine, which was significantly higher than 18.0316.33 /mol creatinine of the control group (P<0.05). From the multiple regression analysis of urinary MDA, the regression coefficient for exposure grade was statistically significant. In future studies, evaluation of the antioxidant levels of subjects should be performed simultaneously with quantitative exposure measurements.
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KEYWORD
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Mixed organic solvents, Malondialdehyde, Job exposure matrix, Painting workers
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