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KMID : 1034820090050020113
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Molecular & Cellular Toxicology
2009 Volume.5 No. 2 p.113 ~ p.119
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Identification of Atherosclerosis Related Gene Expression Profiles by Treatment of Benzo(a)pyrene in Human Umbilical Vein Endothelial Cells
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Lee Sun-Hee
Lee Seung-Eun
Ahn Hyun-Jong
Park Cheung-Seog
Cho Jeong-Je
Park Yong-Seek
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Abstract
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Benzo(a)pyrene (BaP) is a persistent environmental contaminant and is present in tobacco smoke. BaP is considered a major contributor of cardiovascular disease. While the activation of endothelial cells by stimuli including tobacco smoke and air pollution contributes importantly to cardiovascular disease, the nature of BaP’s mechanism is unclear. In this study, gene expression profiles were investigated in BaPtreated human umbilical vein endothelial cells (HUVECs). Various atherosclerosis related genes could be up- and down-regulated more than 2-fold by BaP, and mRNA levels of atherosclerosis related genes encoding apolipoproteinC III, TLR 2, ICAM 1 and exportin 4 were significantly increased by BaP. Our data suggest that BaP-mediated changes in gene expression contribute to the progression of cardiovascular disease.
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KEYWORD
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Benzo(a)pyrene, Cardiovascular disease, Endothelial cells, Gene expression
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