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KMID : 1034820090050020165
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Molecular & Cellular Toxicology
2009 Volume.5 No. 2 p.165 ~ p.171
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Possible Biomarker Gene for Radiation Workers in Hospital
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Jin Young-Woo
Jeong Mee-Seon
Moon Kien
Lee Chee-Young
Bae Sang-Woo
Choi Soo-Yong
Lee Yun-Sil
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Abstract
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Biomarkers indicating past exposure to radiation have not yet been entirely satisfactory. In this study, we validated several genes reported as radiation response genes, as biomarkers to detect past exposure to radiation in occupationally exposed workers, especially workers in the medical field. A total of 54 radiation workers in hospital were investigated for radiation exposure dose. Their average radiation dose of recent one year was 1.09 mSv (1.63) with a 10.63 mSv (12.91) cumulative dose. The results of the multiple regression analysis for the various variables indicate that the Hsc70 (P=0.0292) and ORAL (P=0.0045) may be candidate biomarkers for the recent 1 year radiation exposure in radiation workers, whereas AEN (P=0.0334) and PGAMI (P=0.0003) might be for cumulative exposure.
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KEYWORD
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Candidate biomarkers, Blood lymphocytes, mRNA
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