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KMID : 1034820090050040291
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Molecular & Cellular Toxicology
2009 Volume.5 No. 4 p.291 ~ p.297
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Polymorphisms of Transmembrane Channel-like 1 Gene are Associated with Kawasaki Disease in Korean Population
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Lim Tae-Wan
Kim Su-Kang
Ban Ju-Yeon
Chung Joo-Ho
Song Jeong-Yoon
Yoon Kyung-Lim
Park Sung-Wook
Kim Keon-Sik
Shin Ok-Young
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Abstract
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Kawasaki disease (KD) is believed to be infectious but etiology and the mechanism of development remain elusive. The aim of this study was to investigate the association between transmembrane channel-like 1 (TMC1) gene and KD. One hundred nine KD patients and 424 normal controls were enrolled. Of all KD patients, 34 developed coronary artery lesions (CALs). Eleven single nucleotide polymorphisms (SNPs) within TMC1 gene were selected and SNP genotyping was performed by the direct sequencing. Genotype frequencies were analyzed with the SNPAnalyzer, Helixtree, and SNPStats programs. In the present study, six SNPs (rs7851577, rs10781105, rs2589615, rs1663743, rs1373628, and rs1373626) were significantly associated with the risk of KD. In further haplotype analysis, one haplotype (CGGACCCT) showed a significant association between KD and control groups. These results suggest that TMC1 gene may be a susceptibility gene for KD in Korean population.
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KEYWORD
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Kawasaki disease, Polymorphism, Transmembrane channel-like 1 gene, Haplotype
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