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KMID : 1034820090050040305
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Molecular & Cellular Toxicology
2009 Volume.5 No. 4 p.305 ~ p.309
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Suppressive Effects of Benincasae hispida on Allergic Inflammation
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Park Seul-Ki
Kim Jum-Ji
Sung Sang-Min
Lee Mi-Young
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Abstract
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The effects of an extract of Benincasae hispida on allergic inflammation were examined in terms of histamine and β-hexosaminidase release, serum IgE level and inflammatory cytokine level. The B. hispida extract inhibited the release of histamine and β-hexosaminidase, a degranulation marker, from rat basophilic leukemia cells (RBL-2H3). When mice were first ovalbumin-challenged and then treated with B. hispida extract, there was a significant decrease in the IgE level in the mouse serum. The extract treatment reduced the serum IgE level prominently, compared with the ovalbumin-challenged mice. The extract also significantly reduced the TNF-α and IL-4 levels in the BAL fluid when challenged with antigen. Taken together, the Benincasae hispida extract may be efficacious against allergic inflammation.
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KEYWORD
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Benincasae hispida, Allergic inflammation, Histamine release, Inflammatory cytokine, Serum IgE level
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