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KMID : 1034820090050040328
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Molecular & Cellular Toxicology
2009 Volume.5 No. 4 p.328 ~ p.334
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Immunohistochemical Analysis of TBX3 and -catenin in Gastric Cancers
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Song Jae-Hwi
Yoon Jung-Hwan
Kang Young-Hwi
Cao Zhang
Nam Suk-Woo
Lee Jung-Young
Park Won-Sang
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Abstract
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TBX3 has demonstrated oncogenic activity as a downstream target of the Wnt/β-catenin signaling pathway. In this study, the aim was to determine whether overexpression of the TBX3 protein is involved in the development and/or progression of gastric cancers. We analyzed the expression pattern of the TBX3 and β-catenin proteins in a series of 186 sporadic gastric cancers. Altered expression of the TBX3 and β-catenin proteins was observed in 54 (29.0%) and 48 (25.8%) of the 186 gastric cancers. Statistically, overexpression of the TBX3 and β-catenin proteins was not associated with the clinical and pathological parameters studied including: histological type, tumor location, tumor size, and the 5-year survival (P¤0.05).
However, TBX3 overexpression was closely associated with lymph node metastasis and aberrant β-catenin expression (P?0.05). In addition, overexpression of the TBX3 protein was confirmed by Western blot analysis of primary gastric cancer tissues and cell lines. These data suggest that TBX3 overexpression may play a role in the development and progression
of sporadic gastric cancers.
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KEYWORD
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TBX3, Wnt signaling pathway, Gastric cancer, Expression
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