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KMID : 1034820100060010073
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Molecular & Cellular Toxicology
2010 Volume.6 No. 1 p.73 ~ p.78
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Suppression of TRIF-dependent signaling pathway of Toll-like receptors by oak wood vinegar in RAW264.7 macrophages
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Park Se-Jeong
Youn Hyung-Sun
Lee A-Neum
Back Seong-Kyung
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Abstract
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Toll-like receptors (TLRs) play an important role in initiating innate immune responses. The stimulation of TLRs by microbial components triggers the activation of two downstream signaling pathways: myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interferon-β (TRIF)-dependent signaling pathways. Wood vinegar (WV), a byproduct from charcoal production, has been evaluated for its various biological activities including anti-oxidant, anti-bacterial, and anti-inflammatory activities. To evaluate the therapeutic potential of WV, we examined its effect on signal transduction via the TRIF-dependent pathway of TLRs induced by TLR3 and TLR4 agonists. Oak wood vinegar (OWV) inhibited nuclear factor-κB and interferon regulatory factor 3 activation induced by lipopolysaccharide(LPS) or polyinosinic-polycytidylic acid (poly [I:C]). OWV also inhibited LPS- or poly[I:C]-induced interferon inducible protein-10(IP-10). These results suggest that OWV can modulate TRIF-dependent signaling pathway of TLRs for anti-viral, anti-bacterial, and anti-inflammatory activities.
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KEYWORD
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Toll-like receptors, Wood vinegar, Lipopolysaccharide, Polyinosinic-polycytidylic acid, TRIF
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