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KMID : 1034820100060020143
Molecular & Cellular Toxicology
2010 Volume.6 No. 2 p.143 ~ p.149
Systemic immunity of obese-diabetes model (db/db) mice
Lee Sang-Eun

Jang Ik-Soon
Park Jun-Soo
Lee Ji-Hae
Lee Seung-Yeul
Baek So-Young
Lee Seung-Hoon
Lee Hyun-Ah
Abstract
Obesity has recently been defined as a chronic inflammatory disease and is considered as a major cause of adult health problems including incurable diseases like diabetes and cancer. In this study, the systemic immunity, including the innate and adaptive immunity parameters, of naturally occurring (leptin receptor mutation) obesity-diabetes mice (db/db) was examined to increase our knowledge of these mice for obesity-related studies. Severe fatty liver with blood engorgement was observed in the db/db mice. Compared to background C57BL/6J mice, the adaptive immunity, as measured by mitogen-induced T and B cell proliferation and cytokine release, was significantly suppressed in db/db mice. However, significant upregulation of innate immune-inflammatory parameters including macrophage function and NK cell activity was observed in db/db mice without external stimulation. These data conclusively confirm the systemic immune-inflammatory micro-environment with suppressed adaptive immunity of db/db mice, which may cause the secondary obesity-related life-threatening diseases like diabetes or cancer.
KEYWORD
Obese-diabetes model, Systemic immunity, db/db mice
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