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KMID : 1034820100060040414
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Molecular & Cellular Toxicology
2010 Volume.6 No. 4 p.414 ~ p.420
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Proteomic profiling of the differentially expressed proteins by TiO2 nanoparticles in mouse kidney
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Jeon Yu-Mi
Park Seul-Ki
Rhee Sang-Ki
Lee Mi-Young
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Abstract
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We investigated the proteins showing differential expression in response to TiO2 nanoparticles in mouse kidney using a proteomic approach to better understand the molecular mechanism by which TiO2 nanoparticles-induced nephrotoxicity at the protein level. More than 1,100 protein spots in mouse kidney were detected by the two-dimensional gel eletrophoresis and comparative analysis revealed that the expression of 11 proteins were changed by more than 2 fold in response to TiO2 nanoparticles. Of these, 10 were up-regulated and 1 was down-regulated upon treatment with TiO2 nanoparticles.
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KEYWORD
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Proteomics, TiO2 nanoparticles, Mouse, Kidney, Differentially expressed proteins
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