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KMID : 1034820110070010001
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Molecular & Cellular Toxicology
2011 Volume.7 No. 1 p.1 ~ p.6
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Genetic alterations of the CHOP gene in gastric cancers
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Song Jae-Hwi
Park Jong-Kyung
Yoon Jeong-Whan
Nam Suk-Woo
Lee Jung-Young
Park Won-Sang
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Abstract
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CHOP, a member of the C/EBP family of the transcriptional factor, showed a tumor suppressor activity by binding to TCF and inhibiting the Wnt signaling pathway. In this study, to determine whether genetic alterations of CHOP gene are involved in the development and/or progression of the gastric cancers, we have screened a set of 47 gastric adenoma and 81 sporadic gastric cancers for mutations and allelic loss. In mutation analysis, we found one and five somatic missense mutations, P41T, E69K, S79N, P80S, P80L and G36S, in gastric adenoma and cancer, respectively. All of the mutations were detected in transactivation domain of the CHOP gene. An allelic loss was found in 19 (38.8%) of forty-nine informative cases at one or both microsatellite markers, D12S305 and D12S1691. Clinically, five cancer cases with mutations were of intestinal-type gastric cancers and three mutations were found in the cases with surrounding lymph node metastasis. These data suggest that genetic alterations of the CHOP gene may play an important role in the development of sporadic gastric cancers.
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KEYWORD
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CHOP, Wnt, Gastric cancer, Mutation, Deletion
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