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KMID : 1034820110070010015
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Molecular & Cellular Toxicology
2011 Volume.7 No. 1 p.15 ~ p.24
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Influence of ginsenoside-Re against myocardial infarction in isolated heart
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Kim Hyoung-Bae
Lim Kyu-Hee
Kang Chang-Won
Kim Bum-Seok
Roh Yoon-Seok
Kwon Jung-Kee
Kim Sok-Ho
Ejaz Sohail
Kim Jong-Hoon
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Abstract
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Ginsenosides, one of the well-known traditional herbal substance, frequently are used in South Korea for the prevention of cardiovascular disease. The effects of ginsenoside-Re (G-Re) on ischemia-induced heart were investigated through analyses of hemodynamic change including perfusion pressure, aortic flow, coronary flow, and cardiac output. Myocardial function was recorded. Administration of ginsenoside-Re significantly prevented decreases in perfusion pressure, aortic flow, coronary flow, and cardiac output. The Administration of G-Re significantly recovered all of the hemodynamic parameters, except heart rate, after ischemia-reperfusion (I/R) injury (perfusion pressure: 78.49±3.98% vs. 66.61±3.3%, aortic flow volume: 59.26±2.29% vs. 42.68±2.17%, coronary flow volume: 74.89±2.88% vs. 52.89±2.81%, and cardiac output: 63.12±3.81% vs. 45.25±3.83%, P<0.01, respectively, normal control as 100%). The intracellular calcium ([Ca2+]i) content in cardiomyocytes was quantitatively determined. Administration of G-Re significantly prevented [Ca2+]i increase that had been induced by simulated I/R in vitro (P<0.01) in a dose-dependent manner, suggesting that the antiischemic role of G-Re is mediated by the inhibition of [Ca2+]i increase. Over all, we found that the administration of G-Re has cardioprotective effects on the isolated heart. The beneficial effects may be mediated through controlling the level of [Ca2+]i. These results indicate that G-Re has a distinct cardioprotective effect in an isolated rat heart.
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KEYWORD
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Ginsenoside-Re, Ischemia-reperfusion injury, Hemodynamics
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