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KMID : 1034820110070010095
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Molecular & Cellular Toxicology
2011 Volume.7 No. 1 p.95 ~ p.101
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Analysis of toxicity of tetrabutyltin: comparing with EDC chemicals
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An Yu-Ri
Kim Seung-Jun
Park Hye-Won
Yu So-Yeon
Han Jeong
Oh Jung-Hwa
Yoon Seok-Joo
Hwang Seung-Yong
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Abstract
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Exposure to environmental chemicals has been implicated in a number of adverse health effects, including immunotoxic, neurotoxic, reproductive toxic effects, and, above all, cancers. In the present study, we investigated toxicity of three environmental chemicals-bisphenol A (BPA), nonylphenol (NP), and tetrabutyltin (TTBT) in a human breast cancer cell line by HazChem Human array. We then found toxicity markers of TTBT through comparison with BPA and NP. Fifty three genes were differentially expressed and seventeen genes showed similar expression patterns. Ontology analysis showed differential expression of genes related to aging and apoptosis and genes having similarities associated with pregnancy and insemination. In this paper, we revealed potential TTBT toxic markers and endotoxicity of TTBT. This study could be a foundation for additional studies of TTBT toxicity.
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KEYWORD
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Tetrabutyltin, HazChem Human array, Toxicity, Endotoxic
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