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KMID : 1034820110070020171
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Molecular & Cellular Toxicology
2011 Volume.7 No. 2 p.171 ~ p.176
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A safety assessment of phototoxicity and sensitization of SiO2 nanoparticles
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Choi Jae-Eun
Park Yoon-Hee
Lee Eun-Young
Jeong Sang-Hoon
Kim Sun-Yae
Kim Meyoung-Kon
Son Sang-Wook
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Abstract
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Despite widespread use of silicon dioxide (SiO2) NPs in industry and in our daily lives, no studies so far have evaluated the potential of their skin phototoxicity and sensitization. This study was designed to investigate the potential of phototoxicity and sensitization of SiO2 NPs. Assessment of the potential of skin phototoxicity was carried out using the 3T3 neutral red uptake test, an HSEM, and an animal model. The potential of skin sensitization was evaluated by a non-radioisotope local lymph node assay (non-RI LLNA). Findings from the present study suggest that the HSEM may be a reasonable model system for evaluation of skin phototoxicity of NPs. In addition, our data demonstrate that non-RI LLNA may be a useful method for identification of skin sensitization of NPs. In this study, we showed that SiO2 NPs do not induce phototoxicity or skin sensitization.
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KEYWORD
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SiO2 nanoparticles, Human skin equivalent model, Phototoxicity, Skin sensitization
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