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KMID : 1034820120080030311
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Molecular & Cellular Toxicology
2012 Volume.8 No. 3 p.311 ~ p.315
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Cisplatin induced nephrotoxicity is inhibited by Taxilli Ramulus
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Lee Gi-Hyun
Lee Jun-Ho
Ham Kyoung-Keun
Lee Hyo-Jung
Kim Hyun-Seong
Lee Hyeon-Hoon
Hong Moo-Chang
Shin Min-Kyu
Bae Hyun-Su
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Abstract
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Taxilli Ramulus has been shown have antioxidant and anti-inflammatory activities. Cisplatin is the most active cytotoxic anti-cancer drugs. However, the nephrotoxicity of cisplatin limits its use as a therapeutic. In the present study, we examined whether Taxilli Ramulus could protect against cisplatin induced acute renal failure in mice. Taxilli Ramulus were administrated orally once a day for 3 days (150 or 300 mg/kg body wt). After 3 days, all groups of mice received a single dose of cisplatin (25 mg/kg (body wt)) intraperitoneally. Taxilli Ramulus treatment ameliorated renal dysfunction 72 h after cisplatin injection. Taxilli Ramulus treated group had significantly reduced levels of proinflammatory cytokines when compared to the control group. These results show that Taxilli Ramulus is a potent herbal medicine that can reduce cisplatin nephrotoxicity. It also demonstrates that Taxilli Ramulus can prevent the renal toxic effects caused by cisplatin.
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KEYWORD
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Taxilli Ramulus, Cisplatin, Nephrotoxicity, TNF-α
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