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KMID : 1034820130090010051
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Molecular & Cellular Toxicology
2013 Volume.9 No. 1 p.51 ~ p.56
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Evaluation of comparative cytotoxicity of spray-type chemicals used in household products
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Kwon Jung-Taek
Seo Gyun-Baek
Kim Hyun-Mi
Shim Il-Seob
Lee Byoung-Cheun
Jung Ji-Youn
Kim Pil-Je
Choi Kyung-Hee
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Abstract
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Chemicals are widely used in our daily lives for various purposes such as disinfectant, air fresher, paints and hair spray. However, their pulmonary toxicity has less studied compared with oral and dermal toxicity. Therefore, the purpose of this study was to examine comparative cytotoxicity of triclosan (TCS), benzisothiazolinone (BIT), dichlorophene (DCP) and citral (CTR) major using spray-type chemicals used in household products (CHPs) in Korea. TCS, DCP and BIT induced more severe mitochondria injury and cell membrane damage than CTR in lung epithelial cell during 24 hrs exposure. Furthermore, the result of clonogenic assay revealed that exposure of CHPs significantly decreased colony size and that BIT reduced cell growth at most compared with TCS, DCP and CTR. In summary, results of comparative cytotoxicity demonstrated that inhalation of TCS, DCP and BIT may cause pulmonary toxicity. Therefore, our results suggest that TCS, BIT and DCP are requiring inhalation toxicity assessment for maintaining a high quality of life.
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KEYWORD
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Cytotoxicity, Triclosan, Benzisothiazolinone, Dichlorophene, Citral
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