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KMID : 1034820130090030243
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Molecular & Cellular Toxicology
2013 Volume.9 No. 3 p.243 ~ p.248
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The extract of Tamarindus indica L. suppresses IKKβ activity and NF-κB-dependent lymphoblastoid cell line survival
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Lim Sue-Yeon
Song Yoon-Jae
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Abstract
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The NF-κB family of transcription factors is a critical regulator for the cell survival by inducing the expression of anti-apoptotic genes. In this study, we found that a seventy percent ethanol extract of Tamarindus indica L. (TIE) strongly inhibits both IL-1β- and lipopolysaccharide (LPS)-induced IKKβ and NF-κB activation without affecting the activity of IL-1 receptor associated kinase 1 (IRAK1), which functions upstream of IKKβ. In addition, TIE had no effect on the LPS-induced c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) activation. Furthermore, TIE clearly reduced the viability of NF-κB-dependent lymphoblastoid cell line (LCL) without adversely affecting the viability of NF-κB-independent HeLa cells. Thus, TIE targets IKKβ to inhibit NF-κB activation and LCL viability.
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KEYWORD
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NF-κB, Tamarindus indica L. cell death
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