|
KMID : 1034820130090040393
|
|
Molecular & Cellular Toxicology
2013 Volume.9 No. 4 p.393 ~ p.399
|
|
|
Renoprotective effect of Pulsatillae Radix on cisplatin-induced nephrotoxicity in mice
|
|
Nho Duk-Hee
Lee Hyo-Jung
Keum Dong-June
Lee Gi-Hyun
Lee Chang-Hoon
Lee Jun-Ho
Bae Hyun-Su
|
|
|
Abstract
|
|
|
|
Cisplatin is an effective chemotherapy used to treat tumors. However, the use of cisplatin is limited due to side effects, mainly nephrotoxicity. Pulsatillae Radix is known to possess anti-inflammatory activities. The aim of this study was to test the protective effect of Pulsatilla Radix on cisplatin-induced renal failure in mice. Pulsatillae Radix was administered (300 mg/kg p.o.) once a day for 3 days. At day 3, all groups of mice received a single injection of cisplatin (25 mg/kg i.p.). Pulsatillae Radix treatment ameliorated renal dysfunction 72 h after cisplatin administration. Mice treated with Pulsatillae Radix showed significantly reduced levels of pro-inflammatory cytokines compared to the control group. Moreover, Pulsatillae Radix did not disturb the anti-tumor effect of cisplatin in tumor-bearing mice. These results showed that Pulsatillae Radix has renoprotective effects and may represent a new treatment strategy in cisplatin-induced nephrotoxicity.
|
|
|
KEYWORD
|
|
|
Pulsatilla, Pulsatillae Radix, Cisplatin, Nephrotoxicity, Tumor-bearing mice
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|