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KMID : 1034820130090040415
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Molecular & Cellular Toxicology
2013 Volume.9 No. 4 p.415 ~ p.420
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A polymorphism in DMT1 is associated with lead-related hypertensive status
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Kim Hyung-Ki
Lee Hwa-Young
Kim Hak-Jae
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Abstract
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Divalent metal transporter 1 (DMT1) is an iron transporting membrane protein important for dietary iron uptake and as a carrier of other metals, such as zinc, copper, and lead. This study evaluated the possible association of DMT1 with clinical variables in a lead-exposed population. We investigated three single nucleotide polymorphisms (SNPs) (1303C/A, 1254T/C and IVS4+44C/A) of DMT1 in 662 male lead-exposed workers from Korea using polymerase chain reaction-restriction fragment length polymorphism. Among the three SNPs, the frequencies of IVS4+44C/A were significantly different between normotensive and hypertensive subjects. This suggests that a polymorphism in DMT1 is associated with increased risk of lead-related hypertensive status in a Korean male population.
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KEYWORD
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Lead, Hypertension, Divalent metal transporter 1 (DMT1), Polymorphism
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