|
KMID : 1034820140100010075
|
|
Molecular & Cellular Toxicology
2014 Volume.10 No. 1 p.75 ~ p.82
|
|
|
Emblica officinalis (amla) ameliorates arsenic-induced liver damage via DNA protection by antioxidant systems
|
|
Maiti Smarajit
Chattopadhyay Sandip
Acharyya Nirmallya
Deb Bimal
Hati Amiya Kumar
|
|
|
Abstract
|
|
|
|
Present study demonstrates the therapeutic role of Emblica officinalis (EO) against arsenic-induced DNA and hepatic damage in female rats. Our earlier study on arsenic-exposed human unveils a link between tissue necrosis and carcinogenesis with impaired antioxidant system-associated DNA damage. Here we show ingestion of EO extract (500 mg in 0.1 mL water) in combination with sodium arsenite (0.4 ppm)/100 g b.w. for 24 days to rats offered significant protection against arsenic-induced oxidative damages of DNA and hepatic tissue architecture. Arsenic only exposure decreased hepatic superoxide dismutase, catalase activities and the level of non protein soluble thiol with a concomitant increase in thiobarbituric acid reactive substances and conjugated di-enes which are restrained by EO with a restoration of antioxidant components. In conclusion, restricted generation of free radicals is correlated to DNA protection resulting in prevention of tissue necrosis and possible carcinogenesis.
|
|
|
KEYWORD
|
|
|
Arsenic, Antioxidant systems, DNA fragmentation, Hepatic carcinogenesis, Emblica officinalis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|