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KMID : 1034820140100030251
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Molecular & Cellular Toxicology
2014 Volume.10 No. 3 p.251 ~ p.259
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The extracts of Holotrichia diomphalia larvae inhibit proliferation and induce apoptosis of cancer cells in vitro and in vivo
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Song Lianlian
Sun Shu
Jin Longnan
Xue Lijuan
Fu Yaowen
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Abstract
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Grub extract comes from Holotrichia diomphalia larvae. Numerous studies have demonstrated that grub extracts inhibit the growth of several types of cancer cells in vitro. Here, the anti-tumor activities of grub extracts were observed in experiments performed in vitro and in vivo. Human cervical carcinoma HeLa cells were treated with a range of grub extract doses. Grub extract treatment also resulted in characteristic apoptotic morphological changes in HeLa cells. In vivo acute oral toxicity tests showed that the median lethal dose (LD50) at 5 d was 48.73 g/kg (with 95% confident limits of 46.43?51.14 g/kg) in Kunming mice. Moreover, when the mice were treated with grub extracts at doses of 1.95, 3.9, and 7.8 g/(kg·d) for 10 consecutive days, the solid tumor growth of mice bearing Sl80 was 18.64%, 39.47%, and 53.24%, respectively, relative to the control (P<0.05 or 0.01). These data indicate that grub extracts may inhibit tumor growth and induce apoptotic cell death, and may be a potential and promising natural product to treat tumors.
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KEYWORD
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Holotrichia diomphalia, Grub extracts, HeLa cells, Tumor, Apoptosis, Proliferation
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