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KMID : 1034820140100030329
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Molecular & Cellular Toxicology
2014 Volume.10 No. 3 p.329 ~ p.337
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Subchronic oral toxicity of herbal formula PM012 in Beagle dogs
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Chung Hwan-Suck
Kim Han-Kyum
Kim Dong-Wook
Kim Sun-Kwang
Shim In-Sop
Bae Hyun-Su
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Abstract
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PM012 is a modified oriental medicinal prescription based on Yukmijihwang-tang.We previously reported that PM012 has a neuro-protective effect and has no toxicity with chronic administration in rats. As a process of the development of herbal new drug, we assessed the oral toxicity of PM012 in Beagle dogs. PM012 was administered orally for 28 days at doses of 0, 250, 500, 1000 and 1500 mg/kg/day. When we analyzed the body weight gain, food consumption, clinical observations, blood biochemical, hematology, organ weight ratios and histopathological findings, there were no significant differences between the control and treated groups. It was concluded that orally administered PM012 was safe in dogs, and no treatment-related toxicity was detected, even at the highest doses investigated in repeated dose oral toxicity studies.
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KEYWORD
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PM012, Beagle dogs, Sub-chronic toxicity, Oriental medicinal prescription
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