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KMID : 1034820140100040379
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Molecular & Cellular Toxicology
2014 Volume.10 No. 4 p.379 ~ p.385
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Phthalate-treated endometrial cancer cell lines show increased AKR1C1 expression
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Song Jae-Yeon
Cho Hyun-Hee
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Abstract
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Endometriosis is common benign gynecologic endometrial disorder that causes infertility and pelvic pain. Endometriosis is associated with aberrant inflammatory responses, increased production of prostaglandins, and progesterone resistance. Recently, aldo-keto reductases (1B and 1C) were shown to play an important role in metabolism of prostaglandins and progesterone. In this study, we assessed the aldo-keto reductase gene expression in endometrial cancer cells (ECC)-1 that were treated with phthalate, which has been previously shown to mediate the development of gynecological disorders. The data indicated that phthalate increased expression of aldo-keto reductases in endometrial cells and stimulated production of prostaglandins and may be involved in the development of progesterone resistance.
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KEYWORD
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DEHP, Phthalate, Aldo-keto reductase, Endometriosis
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